About Gene List

PF3D7_0205400

Genome location: Pf3D7_02_v3:222,830..225,455(+)

Genome classification: Core

Function and Localization

Product Description: PCI domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070390 transcription export complex 2
Function GO:0003723 RNA binding
Function GO:0003690 double-stranded DNA binding
Process GO:0071033 nuclear retention of pre-mRNA at the site of transcription
Process GO:0016973 poly(A)+ mRNA export from nucleus
Process GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Process GO:0006368 transcription elongation from RNA polymerase II promoter

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.30 0.85
Trophozoite not expressed 0.39 0.77
Schizont not expressed 0.04 0.97
Gametocyte not expressed 0.23 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0205400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -2.907 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96149

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101860

Most Similar Human Ortholog: Q5JVF3

TM-align score: 0.81 | RMSD: 3.59

Seq Identity: 0.20 | Length: 389 / 457

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000126226 PCI domain containing 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 31 13 23
disruptive 4 15 11 25
missense 4 15 10 21

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 50 21 22
disruptive 6 51 29 99
missense 6 41 21 51

PlasmoDB Total SNPs: 127

Non-coding: 107 | Synonymous: 11 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 457 | Molecular Weight (kDa): 54.351

UniProt ID(s): O96149, Q689D0

PDB ID(s): None

Isoelectric Point: 9.25

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097