About Gene List

PF3D7_0205600

Genome location: Pf3D7_02_v3:227,756..230,583(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.06 0.97
Trophozoite expressed 0.25 0.83
Schizont expressed 0.11 0.92
Gametocyte expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0205600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -3.187 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96151

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=2.18) with 6JWQ (Global RMSD=16.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171439

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 32 29 50
disruptive 6 26 24 44
missense 3 19 21 31

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 82 31 47
disruptive 10 85 41 103
missense 5 56 28 70

PlasmoDB Total SNPs: 134

Non-coding: 99 | Synonymous: 26 | Nonsynonymous: 8 | Stop Codon: 1

Protein Information

Protein Length: 635 | Molecular Weight (kDa): 76.45

UniProt ID(s): O96151

PDB ID(s): None

Isoelectric Point: 5.6

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28288121 A genetic system to study Plasmodium falciparum protein function. Birnbaum J, Flemming S, ..., Spielmann T 10.1038/nmeth.4223