Product Description: PH domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0008289 | lipid binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.05 | 0.97 |
| Trophozoite | no data | 0.29 | 0.82 |
| Schizont | no data | 0.26 | 0.83 |
| Gametocyte | no data | 0.21 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0205800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.243 | MFS: -3.728 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3B1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_110240
Most Similar Human Ortholog: Q9HB21
TM-align score: 0.81 | RMSD: 1.72
Seq Identity: 0.24 | Length: 108 / 120
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000107679 | pleckstrin homology domain containing A1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 3 | 7 |
| disruptive | 0 | 1 | 4 | 14 |
| missense | 0 | 1 | 4 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 16 | 4 | 7 |
| disruptive | 1 | 11 | 8 | 24 |
| missense | 0 | 7 | 8 | 18 |
PlasmoDB Total SNPs: 59
Non-coding: 52 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 120 | Molecular Weight (kDa): 14.405
UniProt ID(s): C6S3B1
PDB ID(s): None
Isoelectric Point: 9.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001849 | Pleckstrin homology domain |
| PFam | PF00169 | Pleckstrin homology domain |
| Superfamily | SSF50729 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27063980 | Identification of Toxoplasma TgPH1, a pleckstrin homology domain-containingprotein that binds to the phosphoinositide PI(3,5)P2. | Daher W, Morlon-Guyot J, ..., Lebrun M | 10.1016/j.molbiopara.2016.03.011 |