Product Description: 26S proteasome regulatory subunit RPN1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0005838 | proteasome regulatory particle |
| Component | GO:0008540 | proteasome regulatory particle, base subcomplex |
| Component | GO:0034515 | proteasome storage granule |
| Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.35 | 0.83 |
| Trophozoite | expressed | 1.14 | 0.43 |
| Schizont | expressed | 0.96 | 0.49 |
| Gametocyte | expressed | 0.64 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0205900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.218 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0303600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0303600)
Modification: Disrupted | RMgm-1752
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96153
"Best" AlphaFill ligand hit: PTY (phosphatidylethanolamine, Local RMSD=0.62) with 7CZ9 (Global RMSD=15.04)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101799
Most Similar Human Ortholog: Q13200
TM-align score: 0.91 | RMSD: 2.58
Seq Identity: 0.42 | Length: 870 / 966
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000175166 | proteasome 26S subunit, non-ATPase 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 52 | 37 | 63 |
| disruptive | 6 | 40 | 32 | 70 |
| missense | 6 | 37 | 31 | 60 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 119 | 42 | 64 |
| disruptive | 15 | 96 | 57 | 126 |
| missense | 13 | 80 | 52 | 95 |
PlasmoDB Total SNPs: 184
Non-coding: 143 | Synonymous: 28 | Nonsynonymous: 12 | Stop Codon: 1
Protein Length: 966 | Molecular Weight (kDa): 108.358
UniProt ID(s): O96153
PDB ID(s): None
Isoelectric Point: 6.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002015 | Proteasome/cyclosome repeat |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR016643 | 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit |
| InterPro | IPR040892 | RPN1, N-terminal |
| InterPro | IPR041433 | 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal |
| PFam | PF01851 | Proteasome/cyclosome repeat |
| PFam | PF17781 | RPN1, N-terminal |
| PFam | PF18051 | 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |