Product Description: cysteine desulfuration protein SufE
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Function | GO:0031071 | cysteine desulfurase activity |
| Function | GO:0008047 | enzyme activator activity |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.23 | 0.85 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | possibly expressed | 0.14 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0206100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.272 | MFS: -3.284 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0303800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0303800)
Modification: Tagged | RMgm-990
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96155
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101206
Most Similar Human Ortholog: Q9Y3E2
TM-align score: 0.27 | RMSD: 5.25
Seq Identity: 0.07 | Length: 73 / 249
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000178096 | bolA family member 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 227
Non-coding: 213 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 249 | Molecular Weight (kDa): 29.104
UniProt ID(s): O96155
PDB ID(s): None
Isoelectric Point: 10.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003808 | Fe-S metabolism associated domain, SufE-like |
| PFam | PF02657 | Fe-S metabolism associated domain, SufE-like |
| Superfamily | SSF82649 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24086138 | The suf iron-sulfur cluster synthesis pathway is required for apicoplastmaintenance in malaria parasites. | Gisselberg JE, Dellibovi-Ragheb TA, ..., Prigge ST | 10.1371/journal.ppat.1003655 |
| 24709262 | Sulfur mobilization for Fe-S cluster assembly by the essential SUF pathway in thePlasmodium falciparum apicoplast and its inhibition. | Charan M, Singh N, ..., Habib S | 10.1128/AAC.02711-13 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 30721667 | Functional analysis of iron-sulfur cluster biogenesis (SUF pathway) fromPlasmodium vivax clinical isolates. | Pala ZR, Saxena V, ..., Garg S | 10.1016/j.exppara.2019.01.015 |