Product Description: pantothenate transporter
SignalP Peptide: N/A
# Transmembrane Domains: 11
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031410 | cytoplasmic vesicle |
| Component | GO:0020009 | microneme |
| Component | GO:0044310 | osmiophilic body |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0015233 | pantothenate transmembrane transporter activity |
| Process | GO:0071976 | cell gliding |
| Process | GO:0035891 | exit from host cell |
| Process | GO:0015887 | pantothenate transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.43 | 0.83 |
| Trophozoite | expressed | 0.11 | 0.93 |
| Schizont | expressed | 0.42 | 0.77 |
| Gametocyte | expressed | 0.37 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0206200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.212 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0303900)
Modification: Mutated | RMgm-1506
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96156
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 29 | 11 | 28 |
| disruptive | 5 | 23 | 15 | 59 |
| missense | 2 | 15 | 14 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 54 | 16 | 33 |
| disruptive | 11 | 60 | 43 | 97 |
| missense | 3 | 37 | 32 | 76 |
PlasmoDB Total SNPs: 138
Non-coding: 123 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 565 | Molecular Weight (kDa): 62.662
UniProt ID(s): O96156
PDB ID(s): None
Isoelectric Point: 7.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011701 | Major facilitator superfamily |
| InterPro | IPR036259 | MFS transporter superfamily |
| PFam | PF07690 | Major facilitator superfamily |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23729665 | Identification and functional analysis of the primary pantothenate transporter,PfPAT, of the human malaria parasite Plasmodium falciparum. | Augagneur Y, Jaubert L, ..., Ben Mamoun C | 10.1074/jbc.M113.482992 |
| 27427910 | A Putative Small Solute Transporter Is Responsible for the Secretion of G377 andTRAP-Containing Secretory Vesicles during Plasmodium Gamete Egress and SporozoiteMotility. | Kehrer J, Singer M, ..., Mair GR | 10.1371/journal.ppat.1005734 |