About Gene List

PF3D7_0206500

Genome location: Pf3D7_02_v3:262,727..268,003(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 1.07 0.54
Trophozoite not expressed 0.63 0.65
Schizont not expressed 0.40 0.76
Gametocyte possibly expressed 0.45 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0206500

Resistome Missense Mutations: N751Y, S754N, V755M, N757Y

Resistome Compounds with Missense Mutations: DSM1

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.886 | MFS: -2.766 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96158

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533734

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 59 41 83
disruptive 57 226 100 208
missense 27 168 78 174

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 32 123 56 86
disruptive 112 429 165 349
missense 54 312 118 235

PlasmoDB Total SNPs: 421

Non-coding: 140 | Synonymous: 157 | Nonsynonymous: 124 | Stop Codon: 0

Protein Information

Protein Length: 1436 | Molecular Weight (kDa): 164.849

UniProt ID(s): O96158

PDB ID(s): None

Isoelectric Point: 10.04

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108