Product Description: DNA-directed RNA polymerase III subunit RPC10, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005666 | RNA polymerase III complex |
| Function | GO:0003700 | DNA-binding transcription factor activity |
| Function | GO:0001056 | RNA polymerase III activity |
| Process | GO:0006386 | termination of RNA polymerase III transcription |
| Process | GO:0006383 | transcription by RNA polymerase III |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.04 | 0.98 |
| Schizont | possibly expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.04 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0206600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0304200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0304200)
Modification: Disrupted | RMgm-1755
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96159
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101491
Most Similar Human Ortholog: Q9Y2Y1
TM-align score: 0.65 | RMSD: 3.21
Seq Identity: 0.22 | Length: 99 / 106
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000161980 | RNA polymerase III subunit K |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 5 | 3 |
| disruptive | 1 | 2 | 2 | 5 |
| missense | 1 | 2 | 2 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 6 | 4 |
| disruptive | 2 | 12 | 8 | 25 |
| missense | 1 | 7 | 6 | 17 |
PlasmoDB Total SNPs: 174
Non-coding: 168 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 106 | Molecular Weight (kDa): 12.595
UniProt ID(s): O96159
PDB ID(s): None
Isoelectric Point: 8.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001222 | Zinc finger, TFIIS-type |
| InterPro | IPR012164 | DNA-directed RNA polymerase subunit/transcription factor S |
| InterPro | IPR034014 | Pol III subunit C11, C-terminal zinc ribbon |
| PFam | PF01096 | Zinc finger, TFIIS-type |
| Superfamily | SSF57783 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |