Product Description: merozoite surface protein 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046658 | anchored component of plasma membrane |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005887 | integral component of plasma membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005886 | plasma membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.90 |
| Trophozoite | expressed | 0.24 | 0.87 |
| Schizont | expressed | 2.73 | 0.11 |
| Gametocyte | expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0206800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.988 | MFS: -2.005 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZX41
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 5 | 2 | 7 |
| disruptive | 60 | 45 | 9 | 30 |
| missense | 42 | 29 | 7 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 11 | 2 | 5 |
| disruptive | 70 | 45 | 19 | 49 |
| missense | 48 | 33 | 12 | 29 |
PlasmoDB Total SNPs: 5
Non-coding: 5 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 272 | Molecular Weight (kDa): 27.957
UniProt ID(s): A0A143ZX41, A0A223LVQ0, A0A223LVQ3, A0A223LVQ4, A0A223LVR7, A0A516RN27, A0A516RN51, A0A516RN83, A0A516RN86, B7SX26, B7SX74, B7SXA6, B7SXB4, B7SXC6, B7SXD3, B7SXD5, B7SXG4, B7SXG6, B7SXI3, J9TCQ5, P50498, Q9GQY7
Isoelectric Point: 5.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001136 | Merozoite surface antigen 2 (MSA-2) |
| PFam | PF00985 | Merozoite surface antigen 2 (MSA-2) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 2181307 | Structural diversity in the 45-kilodalton merozoite surface antigen of Plasmodiumfalciparum. | Smythe JA, Peterson MG, ..., Anders RF | 10.1016/0166-6851(90)90061-p |
| 3293051 | Identification of two integral membrane proteins of Plasmodium falciparum. | Smythe JA, Coppel RL, ..., Anders RF | 10.1073/pnas.85.14.5195 |
| 8992312 | Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of themerozoite surface proteins-1 and -2 of Plasmodium falciparum. | Gerold P, Schofield L, ..., Schwarz RT | 10.1016/0166-6851(95)02518-9 |
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12850259 | Characterisation of the merozoite surface protein-2 promoter using stable andtransient transfection in Plasmodium falciparum. | Wickham ME, Thompson JK, Cowman AF | 10.1016/s0166-6851(03)00118-x |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17881088 | Antibodies induced by Plasmodium falciparum merozoite surface antigen-2-designedpseudopeptides possess neutralizing properties of the in vitro malarialinfection. | Lozano JM, Montoya-Fajardo FJ, ..., Patarroyo ME | 10.1016/j.peptides.2007.07.029 |
| 18577328 | Association of msp-1, msp-2 and pfcrt genes with the severe complications ofPlasmodium falciparum malaria in children. | Sahu PK, Pati SS, Satpathy R | 10.1179/136485908X300814 |
| 18840512 | Differential selective pressures on the merozoite surface protein 2 locus ofPlasmodium falciparum in a low endemic area. | Putaporntip C, Jongwutiwes S, Hughes AL | 10.1016/j.gene.2008.09.009 |
| 19326702 | Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2coding genes and its implications in malaria epidemiology: a review of publishedstudies from 1997-2007. | Kiwanuka GN | https://pubmed.ncbi.nlm.nih.gov/19326702/ |
| 19450733 | Plasmodium falciparum merozoite surface protein 2 is unstructured and formsamyloid-like fibrils. | Adda CG, Murphy VJ, ..., Anders RF | 10.1016/j.molbiopara.2009.03.012 |
| 19502690 | Genetic polymorphism in msp-2, ama-1 and csp genes in Plasmodium falciparum fieldisolates from north and north-western India. | Farooq U, Malla N, Dubey ML | https://pubmed.ncbi.nlm.nih.gov/19502690/ |
| 20478015 | Genetic polymorphism of merozoite surface protein-1 and merozoite surfaceprotein-2 in Plasmodium falciparum field isolates from Myanmar. | Kang JM, Moon SU, ..., Na BK | 10.1186/1475-2875-9-131 |
| 20542076 | Identification of key residues involved in fibril formation by the conservedN-terminal region of Plasmodium falciparum merozoite surface protein 2 (MSP2). | Yang X, Adda CG, ..., Norton RS | 10.1016/j.biochi.2010.06.001 |
| 21189324 | Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoitesurface protein 2 allele-specific human antibodies. | Stubbs J, Olugbile S, ..., Lanzavecchia A | 10.1128/IAI.01034-10 |
| 21809706 | Allelic diversity of merozoite surface protein 2 gene of P falciparum amongchildren in Osogbo, Nigeria. | Ojurongbe O, Fagbenro-Beyioku AF, Adeyeba OA, Kun JF | https://pubmed.ncbi.nlm.nih.gov/21809706/ |
| 22304430 | Role of the helical structure of the N-terminal region of Plasmodium falciparummerozoite surface protein 2 in fibril formation and membrane interaction. | Zhang X, Adda CG, ..., Norton RS | 10.1021/bi201880s |
| 22325817 | Genetic diversity in merozoite surface protein-1 and 2 among Plasmodiumfalciparum isolates from malarious districts of tribal dominant state ofJharkhand, India. | Hussain MM, Sohail M, ..., Raziuddin M | 10.1179/2047773211Y.0000000012 |
| 22463364 | Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrtmutation in Plasmodium falciparum field isolates from Congolese children withasymptomatic infections. | Koukouikila-Koussounda F, Malonga V, ..., Ntoumi F | 10.1186/1475-2875-11-105 |
| 22966050 | Antigenic characterization of an intrinsically unstructured protein, Plasmodiumfalciparum merozoite surface protein 2. | Adda CG, MacRaild CA, ..., Anders RF | 10.1128/IAI.00665-12 |
| 23217196 | Reduction of multiplicity of infections but no change in msp2 genetic diversityin Plasmodium falciparum isolates from Congolese children after introduction ofartemisinin-combination therapy. | Ibara-Okabande R, Koukouikila-Koussounda F, ..., Ntoumi F | 10.1186/1475-2875-11-410 |
| 28542247 | Genetic polymorphism of Merozoite Surface Protein-2 (MSP-2) in Plasmodiumfalciparum isolates from Pawe District, North West Ethiopia. | Mohammed H, Kassa M, ..., Kebede A | 10.1371/journal.pone.0177559 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 30588612 | Interaction of merozoite surface protein 2 with lipid membranes. | Lu C, Zheng X, ..., Zhang X | 10.1002/1873-3468.13320 |
| 31227760 | Immunization with merozoite surface protein 2 fused to a Plasmodium-specificcarrier protein elicits strain-specific and strain-transcending, opsonizingantibody. | Eacret JS, Gonzales DM, Franks RG, Burns JM Jr | 10.1038/s41598-019-45440-4 |
| 32127816 | Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes andmultiplicity of Plasmodium falciparum infection across various endemic areas inSenegal. | Ndiaye T, Sy M, Gaye A, Ndiaye D | 10.4314/ahs.v19i3.19 |
| 33579293 | Genetic polymorphisms of Plasmodium falciparum isolates from Melka-Werer, NorthEast Ethiopia based on the merozoite surface protein-2 (msp-2) gene as amolecular marker. | Mohammed H, Assefa A, ..., Commons RJ | 10.1186/s12936-021-03625-1 |
| 34993632 | Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated fromsymptomatic and asymptomatic malaria subjects in the South of Benin. | Lagnika HO, Moussiliou A, ..., Djogbenou LS | 10.1007/s00436-021-07399-y |
| 36522733 | Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2and multiplicity of infections in western Ethiopia following effective malariainterventions. | Tadele G, Jaiteh FK, ..., Golassa L | 10.1186/s12936-022-04394-1 |
| 37751696 | A genomic platform for surveillance and antigen discovery in Plasmodium spp.using long-read amplicon sequencing | Plaza DF, Zerebinski J, ..., Farnert A | 10.1016/j.crmeth.2023.100574 |
| 37515848 | Are high avidity antibodies to Plasmodium falciparum antigens preferentiallytransferred across the placenta of premature and term babies? | Kayatani AKK, Bobbili N, ..., Taylor DW | 10.1016/j.placenta.2023.07.011 |
| 37653544 | Recent increase in low complexity polygenomic infections and sialicacid-independent invasion pathways in Plasmodium falciparum from Western Gambia | Nganyewo NN, Bojang F, ..., Amambua-Ngwa A | 10.1186/s13071-023-05929-4 |
| 38281044 | msp1, msp2, and glurp genotyping to differentiate Plasmodium falciparumrecrudescence from reinfections during prevention of reestablishment phase, SriLanka, 2014-2019 | Gunasekera KT, Premaratne RG, ..., Fernando DS | 10.1186/s12936-024-04858-6 |
| 37202779 | Prevalence of mutations in the cysteine desulfurase IscS (Pfnfs1) gene inrecurrent Plasmodium falciparum infections following artemether-lumefantrine (AL)and dihydroartemisinin-piperaquine (DP) treatment in Matayos, Western Kenya | Gachie B, Thiong'o K, ..., Kimani F | 10.1186/s12936-023-04587-2 |
| 37545953 | Genetic diversity of Plasmodium falciparum among asymptomatic pregnant women onintermittent preventive treatment with sulfadoxine-pyrimethamine in Nigeria | Olowe RA, Ojo JA, ..., Ojurongbe O | 10.4314/ahs.v23i1.80 |
| 37624380 | Plasmodium falciparum msp-1 and msp-2 genetic diversity and multiplicity ofinfection in isolates from Congolese patients in the Republic of Congo | Baina MT, Djontu JC, ..., Ntoumi F | 10.1007/s00436-023-07951-y |
| 37197082 | Low Allelic Variation of Plasmodium falciparum msp-1 and msp-2 among Gold Minersin Central Kalimantan Province, Indonesia | Arwati H, Lestarisa T, ..., Dachlan YP | 10.18502/ijpa.v18i1.12375 |
| 37689681 | Plasmodium falciparum population structure inferred by msp1 amplicon sequencingof parasites collected from febrile patients in Kenya | Andika B, Mobegi V, ..., Waitumbi J | 10.1186/s12936-023-04700-5 |
| 37456906 | Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P.falciparum diversity throughout treatment in a clinical drug trial | Wamae K, Ndwiga L, ..., Ochola-Oyier L | 10.12688/wellcomeopenres.17736.2 |
| 38392910 | A Comparative Study of Genetic Diversity and Multiplicity of Infection inUncomplicated Plasmodium falciparum Infections in Selected Regions of Pre-Elimination and High Transmission Settings Using MSP1 and MSP2 Genes | Akoniyon OP, Akiibinu M, ..., Okpeku M | 10.3390/pathogens13020172 |
| 37242412 | Comparative study of Plasmodium falciparum msp-1 and msp-2 Genetic Diversity inIsolates from Rural and Urban Areas in the South of Brazzaville, Republic ofCongo | Baina MT, Lissom A, ..., Ntoumi F | 10.3390/pathogens12050742 |
| 37553646 | Evolution of genetic markers for drug resistance after the introduction ofdihydroartemisinin-piperaquine as first-line anti-malarial treatment foruncomplicated falciparum malaria in Indonesia | Rahmasari FV, Asih PBS, ..., Syafruddin D | 10.1186/s12936-023-04658-4 |
| 37849789 | Plasmodium falciparum Genetic Diversity and Resistance Genotype Profile inInfected Placental Samples Collected After Delivery in Ouagadougou | Sawadogo H, Soulama I, ..., Savadogo A | 10.2147/IDR.S420004 |