About Gene List

PF3D7_0206900 (MSP5)

Genome location: Pf3D7_02_v3:274,946..276,712(-)

Genome classification: Core

Function and Localization

Product Description: merozoite surface protein 5

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005886 plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte possibly expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0206900.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.988 | MFS: -2.098 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q7KWJ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532523

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 6 6 14
disruptive 5 22 14 34
missense 5 21 10 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 14 9 9
disruptive 12 42 38 68
missense 10 32 30 37

PlasmoDB Total SNPs: 115

Non-coding: 101 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 272 | Molecular Weight (kDa): 30.974

UniProt ID(s): J7GNK9, O76245, Q58SP9, Q7KWJ3, Q8I0H3, Q8ITM0, Q9U8B4

PDB ID(s): None

Isoelectric Point: 4.37

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000742 EGF-like domain
PFam N/A N/A
Superfamily SSF57196 N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
37978446 Genetic diversity of merozoite surface protein-5 (MSP-5) of Plasmodium vivaxisolates from Malaria patients in Iran Mansouri S, Heidari A, ..., Mahmoudi E 10.1186/s12879-023-08804-w
37754682 Associations between prenatal malaria exposure, maternal antibodies at birth, andmalaria susceptibility during the first year of life in Burkina Faso Natama HM, Moncunill G, ..., Dobano C 10.1128/iai.00268-23