About Gene List

PF3D7_0207100

Genome location: Pf3D7_02_v3:281,275..287,696(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.35 0.86
Trophozoite expressed 1.11 0.48
Schizont expressed 1.71 0.36
Gametocyte expressed 1.01 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0207100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.608 | #Insertions: 5

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0304500)

  • Relative Growth Rate: 0.38 ± 0.07
  • Confidence: 6.77

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0304500)

Modification: Disrupted | RMgm-1757

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96160

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=2.32) with 3OTT (Global RMSD=18.92)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_170897

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 18 58 38 68
disruptive 53 141 91 228
missense 42 129 81 201

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 99 57 86
disruptive 91 325 149 344
missense 55 274 126 239

PlasmoDB Total SNPs: 307

Non-coding: 130 | Synonymous: 106 | Nonsynonymous: 71 | Stop Codon: 0

Protein Information

Protein Length: 1745 | Molecular Weight (kDa): 207.845

UniProt ID(s): A0A143ZXZ0, O96160

PDB ID(s): None

Isoelectric Point: 9.83

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097