Product Description: iron-sulfur assembly protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Function | GO:0005506 | iron ion binding |
| Process | GO:0016226 | iron-sulfur cluster assembly |
| Process | GO:0051604 | protein maturation |
| Process | GO:0106035 | protein maturation by [4Fe-4S] cluster transfer |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.12 | 0.92 |
| Schizont | not expressed | 0.34 | 0.80 |
| Gametocyte | not expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0207200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.195 | MFS: -3.514 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0304600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96161
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101909
Most Similar Human Ortholog: Q86U28
TM-align score: 0.67 | RMSD: 2.92
Seq Identity: 0.30 | Length: 122 / 160
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165898 | iron-sulfur cluster assembly 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 4 | 6 |
| disruptive | 2 | 4 | 4 | 17 |
| missense | 2 | 4 | 4 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 11 | 7 | 6 |
| disruptive | 3 | 18 | 12 | 24 |
| missense | 2 | 16 | 11 | 11 |
PlasmoDB Total SNPs: 44
Non-coding: 38 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 160 | Molecular Weight (kDa): 18.402
UniProt ID(s): O96161
PDB ID(s): None
Isoelectric Point: 9.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000361 | FeS cluster biogenesis |
| InterPro | IPR016092 | FeS cluster insertion protein |
| InterPro | IPR035903 | HesB-like domain superfamily |
| PFam | PF01521 | FeS cluster biogenesis |
| Superfamily | SSF89360 | HesB-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34032321 | [Fe-S] biogenesis and unusual assembly of the ISC scaffold complex in thePlasmodium falciparum mitochondrion. | Mohammad Sadik, Mohammad Afsar, Ramachandran R, Habib S | 10.1111/mmi.14735 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |