Product Description: serine repeat antigen 2
SignalP Peptide: MKFHISFFLILYIVFFKNTIKS
# Transmembrane Domains: 0
EC Numbers: 3.4.22.- (Cysteine endopeptidases.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005615 | extracellular space |
| Component | GO:0005764 | lysosome |
| Function | GO:0004197 | cysteine-type endopeptidase activity |
| Function | GO:0008234 | cysteine-type peptidase activity |
| Process | GO:0002377 | immunoglobulin production |
| Process | GO:0006508 | proteolysis |
| Process | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| Process | GO:0050776 | regulation of immune response |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.12 | 0.93 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.04 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0207900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.99 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0305100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96166
"Best" AlphaFill ligand hit: I3C (5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Local RMSD=0.39) with 6X42 (Global RMSD=1.98)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.22.- | Ex: staphylococcal cysteine proteinase | NEME64SpiSDSCysEDTAPCMBEGTAPMSFTLCKTPCKMENT... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 27 | 16 | 53 |
| disruptive | 52 | 97 | 58 | 131 |
| missense | 47 | 87 | 57 | 125 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 49 | 25 | 58 |
| disruptive | 72 | 175 | 84 | 155 |
| missense | 66 | 154 | 80 | 138 |
PlasmoDB Total SNPs: 215
Non-coding: 84 | Synonymous: 43 | Nonsynonymous: 88 | Stop Codon: 0
Protein Length: 1105 | Molecular Weight (kDa): 124.895
UniProt ID(s): A0A0E3VL23, A0A0E3VL30, A0A0E3VL39, A0A0E4B1U7, A0A0E4B1V4, A0A0E4B237, A0A0E4B379, A0A0E4B3F9, A0A0E4FJB2, O96166
PDB ID(s): None
Isoelectric Point: 6.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000668 | Peptidase C1A, papain C-terminal |
| InterPro | IPR025661 | Cysteine peptidase, asparagine active site |
| InterPro | IPR038765 | Papain-like cysteine peptidase superfamily |
| PFam | PF00112 | Peptidase C1A, papain C-terminal |
| Superfamily | SSF54001 | Papain-like cysteine peptidase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12228245 | A subset of Plasmodium falciparum SERA genes are expressed and appear to play animportant role in the erythrocytic cycle. | Miller SK, Good RT, ..., Crabb BS | 10.1074/jbc.M206974200 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23634205 | The role of serine-type serine repeat antigen in Plasmodium yoelii blood stagedevelopment | Huang X, Liew K, ..., Preiser PR | 10.1371/journal.pone.0060723 |
| 7891737 | Analysis of stage-specific transcripts of the Plasmodium falciparum serine repeatantigen (SERA) gene and transcription from the SERA locus | Fox BA, Bzik DJ | 10.1016/0166-6851(94)00162-6 |
| 31262308 | Detection of low-density Plasmodium falciparum infections using amplicon deepsequencing | Early AM, Daniels RF, ..., Neafsey DE | 10.1186/s12936-019-2856-1 |
| 37662206 | Analytic optimization of Plasmodium falciparum marker gene haplotype recoveryfrom amplicon deep sequencing of complex mixtures | Lapp Z, Freedman E, ..., Taylor SM | 10.1101/2023.08.17.23294237 |