About Gene List

PF3D7_0208100

Genome location: Pf3D7_02_v3:327,442..335,433(+)

Genome classification: Core

Function and Localization

Product Description: C2 domain-containing protein 5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Component GO:0005886 plasma membrane
Function GO:0005509 calcium ion binding
Function GO:0005544 calcium-dependent phospholipid binding
Process GO:0065002 intracellular protein transmembrane transport
Process GO:0010828 positive regulation of glucose transmembrane transport
Process GO:0090314 positive regulation of protein targeting to membrane
Process GO:0031340 positive regulation of vesicle fusion
Process GO:0072659 protein localization to plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed nd nd
Trophozoite possibly expressed nd nd
Schizont expressed nd nd
Gametocyte expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0208100.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.081 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96168

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104702

Most Similar Human Ortholog: Q86YS7

TM-align score: 0.68 | RMSD: 4.40

Seq Identity: 0.26 | Length: 751 / 1789

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000111731 C2 calcium dependent domain containing 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 95 59 120
disruptive 77 232 94 294
missense 39 165 81 233

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 34 198 67 126
disruptive 167 473 191 356
missense 71 335 150 243

PlasmoDB Total SNPs: 435

Non-coding: 259 | Synonymous: 100 | Nonsynonymous: 76 | Stop Codon: 0

Protein Information

Protein Length: 1789 | Molecular Weight (kDa): 211.887

UniProt ID(s): O96168, Q8WSS7

PDB ID(s): None

Isoelectric Point: 9.15

Protein Domain Annotations:

Source Family ID Description
InterPro IPR038983 C2 domain-containing protein 5
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097