Product Description: KRR1 small subunit processome component, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Component | GO:0030688 | preribosome, small subunit precursor |
| Component | GO:0032040 | small-subunit processome |
| Process | GO:0006364 | rRNA processing |
| Process | GO:0042274 | ribosomal small subunit biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.17 | 0.49 |
| Trophozoite | expressed | 0.83 | 0.57 |
| Schizont | expressed | 0.21 | 0.88 |
| Gametocyte | expressed | 0.61 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0208200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.372 | MFS: -2.666 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0305300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96169
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102159
Most Similar Human Ortholog: Q13601
TM-align score: 0.83 | RMSD: 2.46
Seq Identity: 0.53 | Length: 267 / 300
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000111615 | KRR1 small subunit processome component homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 12 | 19 |
| disruptive | 3 | 15 | 4 | 35 |
| missense | 3 | 14 | 3 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 34 | 13 | 19 |
| disruptive | 7 | 44 | 26 | 85 |
| missense | 5 | 31 | 22 | 44 |
PlasmoDB Total SNPs: 65
Non-coding: 53 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 300 | Molecular Weight (kDa): 36.075
UniProt ID(s): O96169
PDB ID(s): None
Isoelectric Point: 10.42
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024166 | Ribosomal RNA assembly KRR1 |
| InterPro | IPR036612 | K Homology domain, type 1 superfamily |
| InterPro | IPR041174 | Krr1, KH1 domain |
| PFam | PF17903 | Krr1, KH1 domain |
| Superfamily | SSF54791 | K Homology domain, type 1 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28428983 | Rapid inducible protein displacement in Plasmodiumin vivo and in vitro usingknocksideways technology. | Hughes KR, Waters AP | 10.12688/wellcomeopenres.11005.1 |
| 31895625 | A Drug Repurposing and Protein-Protein Interaction Network Study ofRibosomopathies Using Yeast as a Model System | Ertekin E, Gencturk E, Kasim M, Ulgen KO | 10.1089/omi.2019.0096 |