Product Description: histidine phosphatase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0016791 | phosphatase activity |
| Process | GO:0016311 | dephosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.56 | 0.75 |
| Trophozoite | expressed | 1.28 | 0.40 |
| Schizont | expressed | 1.44 | 0.38 |
| Gametocyte | expressed | 1.46 | 0.35 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0208400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.355 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96171
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100295
Most Similar Human Ortholog: A0A087WWB7
TM-align score: 0.57 | RMSD: 3.16
Seq Identity: 0.12 | Length: 59 / 2010
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000014257 | acid phosphatase 3 |
| ENSG00000134575 | acid phosphatase 2, lysosomal |
| ENSG00000162836 | acid phosphatase 6, lysophosphatidic |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 91 | 45 | 130 |
| disruptive | 90 | 400 | 217 | 412 |
| missense | 58 | 291 | 172 | 316 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 189 | 70 | 171 |
| disruptive | 202 | 877 | 344 | 653 |
| missense | 104 | 611 | 258 | 397 |
PlasmoDB Total SNPs: 431
Non-coding: 120 | Synonymous: 180 | Nonsynonymous: 131 | Stop Codon: 0
Protein Length: 2010 | Molecular Weight (kDa): 241.793
UniProt ID(s): O96171
PDB ID(s): None
Isoelectric Point: 10.1
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR029033 | Histidine phosphatase superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF53254 | Histidine phosphatase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |