Product Description: acyl carrier protein
SignalP Peptide: MKILLLCIIFLYYVNA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Function | GO:0000035 | acyl binding |
| Function | GO:0000036 | acyl carrier activity |
| Function | GO:0008897 | holo-[acyl-carrier-protein] synthase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.19 | 0.87 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0208500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.231 | MFS: -3.465 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0305600)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0305600)
Modification: Tagged | RMgm-638
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KWJ1
"Best" AlphaFill ligand hit: PAM (palmitoleic acid, Local RMSD=0.02) with 6C0B (Global RMSD=14.54)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P52505 | Acyl carrier protein, mitochondrial | Bos taurus | OrthoDB | CHEMBL208980CHEMBL379529CHEMBL208839CHEMBL464549... |
Ortholog Group (OrthoMCL): OG6_100820
Most Similar Human Ortholog: I3L505
TM-align score: 0.72 | RMSD: 2.56
Seq Identity: 0.38 | Length: 68 / 137
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000004779 | NADH:ubiquinone oxidoreductase subunit AB1 |
Protein Length: 137 | Molecular Weight (kDa): 15.809
PDB ID(s): None
Isoelectric Point: 9.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003231 | Acyl carrier protein (ACP) |
| InterPro | IPR006162 | Phosphopantetheine attachment site |
| InterPro | IPR009081 | Phosphopantetheine binding ACP domain |
| InterPro | IPR036736 | ACP-like superfamily |
| PFam | PF00550 | Phosphopantetheine binding ACP domain |
| Superfamily | SSF47336 | ACP-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 151
Non-coding: 140 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 10775264 | Protein trafficking to the plastid of Plasmodium falciparum is via the secretorypathway. | Waller RF, Reed MB, Cowman AF, McFadden GI | 10.1093/emboj/19.8.1794 |
| 12270624 | Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacylACP synthase III (PfKASIII) from Plasmodium falciparum. | Waters NC, Kopydlowski KM, ..., Prigge ST | 10.1016/s0166-6851(02)00140-8 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17555524 | Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparumacyl carrier protein. Role of the 4'-phosphopantetheine group in the stability ofthe holo form of Plasmodium falciparum acyl carrier protein. | Modak R, Sinha S, Surolia N | 10.1111/j.1742-4658.2007.05856.x |
| 19462023 | Catalysis and mechanism of malonyl transferase activity in type II fatty acidbiosynthesis acyl carrier proteins. | Misra A, Surolia N, Surolia A | 10.1039/b820420a |
| 28462015 | Membrane and luminal proteins reach the apicoplast by different traffickingpathways in the malaria parasite Plasmodium falciparum. | Chaudhari R, Dey V, ..., Patankar S | 10.7717/peerj.3128 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34612205 | Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesisfrom fatty acid synthesis in malaria parasites | Falekun S, Sepulveda J, ..., Sigala PA | 10.7554/eLife.71636 |