Product Description: ribosome-recycling factor
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0043023 | ribosomal large subunit binding |
| Process | GO:0032790 | ribosome disassembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.99 | 0.50 |
| Schizont | expressed | 0.36 | 0.78 |
| Gametocyte | possibly expressed | 0.34 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0208600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.183 | MFS: -2.794 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0521800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96173
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101101
Most Similar Human Ortholog: Q96E11
TM-align score: 0.52 | RMSD: 3.92
Seq Identity: 0.06 | Length: 177 / 498
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148187 | mitochondrial ribosome recycling factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 22 | 11 | 25 |
| disruptive | 41 | 95 | 44 | 96 |
| missense | 14 | 61 | 31 | 76 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 37 | 28 | 31 |
| disruptive | 67 | 190 | 81 | 149 |
| missense | 27 | 121 | 55 | 81 |
PlasmoDB Total SNPs: 125
Non-coding: 59 | Synonymous: 30 | Nonsynonymous: 36 | Stop Codon: 0
Protein Length: 498 | Molecular Weight (kDa): 60.532
UniProt ID(s): O96173
PDB ID(s): None
Isoelectric Point: 4.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002661 | Ribosome recycling factor |
| InterPro | IPR023584 | Ribosome recycling factor domain |
| InterPro | IPR036191 | RRF superfamily |
| PFam | PF01765 | Ribosome recycling factor domain |
| Superfamily | SSF55194 | RRF superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23614815 | Recycling factors for ribosome disassembly in the apicoplast and mitochondrion ofPlasmodium falciparum. | Gupta A, Mir SS, ..., Habib S | 10.1111/mmi.12230 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 27257059 | Ribosome recycling defects modify the balance between the synthesis and assemblyof specific subunits of the oxidative phosphorylation complexes in yeastmitochondria | Ostojic J, Panozzo C, ..., Bonnefoy N | 10.1093/nar/gkw490 |
| 26309257 | Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein KinaseA-dependent Transcription in Saccharomyces cerevisiae | Nicastro R, Tripodi F, ..., Coccetti P | 10.1074/jbc.M115.658005 |
| 25002117 | A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxiccytochrome c oxidase activity | Hess KC, Liu J, ..., Barrientos A | 10.1096/fj.14-252890 |
| 23172850 | The genetic architecture of biofilm formation in a clinical isolate ofSaccharomyces cerevisiae | Granek JA, Murray D, Kayrkci O, Magwene PM | 10.1534/genetics.112.142067 |
| 28888990 | Chemicals or mutations that target mitochondrial translation can rescue therespiratory deficiency of yeast bcs1 mutants | Panozzo C, Laleve A, ..., Dujardin G | 10.1016/j.bbamcr.2017.09.003 |