PF3D7_0208700

Genome location: Pf3D7_02_v3:356,196..358,035(-)

Genome classification: Core

Function and Localization

Product Description: SHS2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0208700.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.872 | MFS: -1.746 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0305800)

• Relative Growth Rate: 0.36 ± 0.14
• Confidence: 5.34

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0305800)

Modification: Disrupted | RMgm-1767

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I662

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103646

Most Similar Human Ortholog: Q3B726

TM-align score: 0.65 | RMSD: 3.02

Seq Identity: 0.13 | Length: 168 / 222

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 129

Non-coding: 114 | Synonymous: 14 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 222 | Molecular Weight (kDa): 26.371

UniProt ID(s): Q8I662

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations: