About Gene List

PF3D7_0208800

Genome location: Pf3D7_02_v3:358,084..360,086(+)

Genome classification: Core

Function and Localization

Product Description: protein P22, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol
Component GO:0005886 plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.16 0.92
Trophozoite not expressed 0.36 0.78
Schizont not expressed 0.08 0.94
Gametocyte not expressed 0.38 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0208800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -2.83 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0305900)

Modification: Mutated | RMgm-5271

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96174

"Best" AlphaFill ligand hit: TEW (6-tungstotellurate(vi), Local RMSD=0.56) with 6NYS (Global RMSD=14.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533623

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 10 19
disruptive 8 22 15 27
missense 8 21 14 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 29 12 9
disruptive 14 54 23 66
missense 10 48 20 37

PlasmoDB Total SNPs: 121

Non-coding: 94 | Synonymous: 22 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 235 | Molecular Weight (kDa): 28.164

UniProt ID(s): O96174

PDB ID(s): None

Isoelectric Point: 8.91

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
33222390 A conserved malaria parasite antigen Pb22 plays a critical role in malegametogenesis in Plasmodium berghei. Liu F, Yang F, ..., Cao Y 10.1111/cmi.13294