About Gene List

PF3D7_0209100 (PATPL1)

Genome location: Pf3D7_02_v3:380,935..384,245(-)

Genome classification: Core

Function and Localization

Product Description: patatin-like phospholipase 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.1.4 (Phospholipase A(2))

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol
Function GO:0004623 phospholipase A2 activity
Function GO:0004620 phospholipase activity
Process GO:0006644 phospholipid metabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.37 0.82
Trophozoite possibly expressed 0.40 0.75
Schizont expressed 0.21 0.86
Gametocyte possibly expressed 0.31 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0209100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.821 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96176

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.1.4 phospholipase A2 BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144769

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 25 20 37
disruptive 12 31 21 65
missense 10 29 21 61

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 56 27 42
disruptive 18 89 44 118
missense 13 74 43 97

PlasmoDB Total SNPs: 107

Non-coding: 75 | Synonymous: 25 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 679 | Molecular Weight (kDa): 78.305

UniProt ID(s): O96176

PDB ID(s): None

Isoelectric Point: 5.4

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002641 Patatin-like phospholipase domain
InterPro IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
PFam PF01734 Patatin-like phospholipase domain
Superfamily SSF52151 Acyl transferase/acyl hydrolase/lysophospholipase

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31413195 Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis andmalaria transmission. Singh P, Alaganan A, ..., Chitnis CE 10.1073/pnas.1900266116
31734953 A patatin-like phospholipase functions during gametocyte induction in the malariaparasite Plasmodium falciparum. Flammersfeld A, Panyot A, ..., Pradel G 10.1111/cmi.13146