Product Description: ARMT1-like domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.- (Phosphoric monoester hydrolases.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0016791 | phosphatase activity |
| Process | GO:2001020 | regulation of response to DNA damage stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.10 | 0.95 |
| Trophozoite | not expressed | 0.33 | 0.79 |
| Schizont | not expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0209400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.993 | MFS: -2.677 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0306500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0306500)
Modification: Disrupted | RMgm-1770
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3B4
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.- | Ex: 2-lysophosphatidate phosphatase | ATPGTPGDPNaFAMPEDTAHgCl2CuSO4FeCl3AlCl3CHAPSNa3VO4... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102304
Most Similar Human Ortholog: F5GZY1
TM-align score: 0.87 | RMSD: 2.31
Seq Identity: 0.29 | Length: 300 / 450
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000146476 | acidic residue methyltransferase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 18 | 8 | 29 |
| disruptive | 3 | 41 | 30 | 71 |
| missense | 3 | 41 | 29 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 37 | 20 | 28 |
| disruptive | 11 | 98 | 49 | 112 |
| missense | 9 | 88 | 48 | 91 |
PlasmoDB Total SNPs: 176
Non-coding: 151 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 450 | Molecular Weight (kDa): 54.468
UniProt ID(s): C6S3B4
PDB ID(s): None
Isoelectric Point: 5.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002791 | Domain of unknown function DUF89 |
| InterPro | IPR036075 | AF1104-like superfamily |
| InterPro | IPR039763 | Protein-glutamate O-methyltransferase |
| PFam | PF01937 | Domain of unknown function DUF89 |
| Superfamily | SSF111321 | AF1104-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |