PF3D7_0209500

Genome location: Pf3D7_02_v3:391,238..392,887(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.93
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.29	0.86
Gametocyte	not expressed	0.38	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0209500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.47 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0306600)

Relative Growth Rate: 1.06 ± 0.14
Confidence: 5.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0306600)

Modification: Disrupted | RMgm-1771

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96179

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532851

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	22	14	18
disruptive	15	45	43	78
missense	11	41	42	70

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	42	10	33
disruptive	29	120	57	127
missense	16	102	53	93

PlasmoDB Total SNPs: 44

Non-coding: 25 | Synonymous: 8 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 504 | Molecular Weight (kDa): 58.355

UniProt ID(s): O96179

PDB ID(s): None

Isoelectric Point: 10.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097