PF3D7_0209600

Genome location: Pf3D7_02_v3:393,969..399,286(-)

Genome classification: Core

Function and Localization

Product Description: transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 13

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Component	GO:0005886	plasma membrane
Process	GO:0035725	sodium ion transmembrane transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.14	0.93
Trophozoite	expressed	0.20	0.88
Schizont	expressed	0.65	0.62
Gametocyte	expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0209600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.136 | MFS: -2.867 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0306700)

Relative Growth Rate: 0.18 ± 0.12
Confidence: 5.70

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96181

"Best" AlphaFill ligand hit: CLR (cholesterol, Local RMSD=0.06) with 7WGD (Global RMSD=2.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117850

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	68	35	73
disruptive	20	74	46	93
missense	14	65	44	77

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	127	61	73
disruptive	39	172	79	202
missense	27	131	69	111

PlasmoDB Total SNPs: 279

Non-coding: 197 | Synonymous: 65 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 1132 | Molecular Weight (kDa): 133.698

UniProt ID(s): O96181

PDB ID(s): None

Isoelectric Point: 8.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR037272	Sodium:neurotransmitter symporter superfamily
PFam	PF00209	Sodium:neurotransmitter symporter
Superfamily	SSF161070	Sodium:neurotransmitter symporter superfamily

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097