Genome location: Pf3D7_02_v3:409,983..411,199(+)
Genome classification: Core
Product Description: secretory complex protein 61 gamma subunit
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005784 | Sec61 translocon complex |
| Component | GO:0071261 | Ssh1 translocon complex |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Function | GO:0008320 | protein transmembrane transporter activity |
| Process | GO:0031204 | posttranslational protein targeting to membrane, translocation |
| Process | GO:0043952 | protein transport by the Sec complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.16 | 0.92 |
| Trophozoite | expressed | 0.28 | 0.82 |
| Schizont | expressed | 0.17 | 0.88 |
| Gametocyte | expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0210000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.121 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0306900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96183
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101625
Most Similar Human Ortholog: P60059
TM-align score: 0.96 | RMSD: 0.71
Seq Identity: 0.50 | Length: 68 / 81
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132432 | SEC61 translocon subunit gamma |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 5 | 3 | 1 |
| disruptive | 0 | 0 | 0 | 2 |
| missense | 0 | 0 | 0 | 1 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 0 | 2 |
| disruptive | 1 | 4 | 4 | 11 |
| missense | 0 | 2 | 4 | 6 |
PlasmoDB Total SNPs: 127
Non-coding: 122 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 81 | Molecular Weight (kDa): 9.286
UniProt ID(s): O96183
PDB ID(s): None
Isoelectric Point: 8.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001901 | Protein translocase complex, SecE/Sec61-gamma subunit |
| InterPro | IPR008158 | Protein translocase SEC61 complex, gamma subunit |
| InterPro | IPR023391 | Protein translocase SecE domain superfamily |
| PFam | PF00584 | Protein translocase complex, SecE/Sec61-gamma subunit |
| Superfamily | SSF103456 | Protein translocase SecE domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17919451 | Unraveling the components of protein translocation pathway in human malariaparasite Plasmodium falciparum. | Tuteja R | 10.1016/j.abb.2007.08.031 |
| 20450886 | The mammalian and yeast translocon complexes comprise a characteristic Sec61channel | Erdmann F, Jung M, ..., Wagner R | 10.1016/j.bbrc.2010.04.168 |