Product Description: 60S ribosomal protein L37ae, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0210100.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.126 | MFS: -3.711 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZYX3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100717
Most Similar Human Ortholog: Q6P4E4
TM-align score: 0.99 | RMSD: 0.33
Seq Identity: 0.65 | Length: 72 / 96
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197756 | ribosomal protein L37a |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 3 | 6 | 6 |
| disruptive | 0 | 2 | 1 | 6 |
| missense | 0 | 2 | 1 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 6 | 7 |
| disruptive | 0 | 9 | 4 | 16 |
| missense | 0 | 4 | 3 | 9 |
PlasmoDB Total SNPs: 42
Non-coding: 38 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 96 | Molecular Weight (kDa): 10.799
UniProt ID(s): A0A143ZYX3, O96184
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002674 | Ribosomal protein L37ae |
| InterPro | IPR011332 | Zinc-binding ribosomal protein |
| PFam | PF01780 | Ribosomal protein L37ae |
| Superfamily | SSF57829 | Zinc-binding ribosomal protein |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |