About Gene List

PF3D7_0210200

Genome location: Pf3D7_02_v3:412,948..421,861(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005730 nucleolus
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.22 0.90
Trophozoite expressed 1.55 0.33
Schizont expressed 1.06 0.53
Gametocyte expressed 1.53 0.35

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0210200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.859 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWL6

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=11.14) with 8BIC (Global RMSD=16.78)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532595

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 34 107 65 137
disruptive 246 359 155 401
missense 109 196 102 266

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 52 196 95 125
disruptive 344 623 270 506
missense 144 375 175 325

PlasmoDB Total SNPs: 595

Non-coding: 154 | Synonymous: 212 | Nonsynonymous: 227 | Stop Codon: 2

Protein Information

Protein Length: 2588 | Molecular Weight (kDa): 310.026

UniProt ID(s): A0A143ZWL6

PDB ID(s): None

Isoelectric Point: 6.37

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28288121 A genetic system to study Plasmodium falciparum protein function. Birnbaum J, Flemming S, ..., Spielmann T 10.1038/nmeth.4223