Product Description: monocarboxylate transporter, putative
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Function | GO:0008028 | monocarboxylic acid transmembrane transporter activity |
| Process | GO:0015718 | monocarboxylic acid transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.04 | 0.97 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0210300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.961 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96186
"Best" AlphaFill ligand hit: 2OP ((2s)-2-hydroxypropanoic acid, Local RMSD=0.33) with 6HCL (Global RMSD=1.90)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 26 | 12 | 26 |
| disruptive | 0 | 10 | 8 | 28 |
| missense | 0 | 10 | 7 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 41 | 20 | 30 |
| disruptive | 3 | 31 | 16 | 53 |
| missense | 1 | 22 | 15 | 41 |
PlasmoDB Total SNPs: 225
Non-coding: 204 | Synonymous: 17 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 457 | Molecular Weight (kDa): 51.861
UniProt ID(s): O96186
PDB ID(s): None
Isoelectric Point: 8.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011701 | Major facilitator superfamily |
| InterPro | IPR036259 | MFS transporter superfamily |
| PFam | PF07690 | Major facilitator superfamily |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |