About Gene List

PF3D7_0210500

Genome location: Pf3D7_02_v3:427,161..431,611(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.22 0.90
Trophozoite not expressed 0.55 0.70
Schizont not expressed 0.14 0.93
Gametocyte not expressed 0.57 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0210500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.092 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96187

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=22.94) with 2PML (Global RMSD=26.19)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532866

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 46 19 57
disruptive 39 145 100 195
missense 27 127 89 173

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 82 51 64
disruptive 69 329 149 294
missense 39 277 122 207

PlasmoDB Total SNPs: 141

Non-coding: 50 | Synonymous: 49 | Nonsynonymous: 42 | Stop Codon: 0

Protein Information

Protein Length: 1346 | Molecular Weight (kDa): 163.339

UniProt ID(s): O96187

PDB ID(s): None

Isoelectric Point: 9.19

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097