Product Description: syntaxin, Qa-SNARE family
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031201 | SNARE complex |
| Component | GO:0012505 | endomembrane system |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006887 | exocytosis |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0048278 | vesicle docking |
| Process | GO:0006906 | vesicle fusion |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | not expressed | 0.03 | 0.98 |
| Schizont | not expressed | 0.18 | 0.90 |
| Gametocyte | possibly expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0210700
Resistome Missense Mutations: K53N
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.21 | MFS: -3.264 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1012900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96189
"Best" AlphaFill ligand hit: VIB (3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium, Local RMSD=0.68) with 4KYS (Global RMSD=17.05)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100497
Most Similar Human Ortholog: A0A0C4DFZ1
TM-align score: 0.64 | RMSD: 3.70
Seq Identity: 0.20 | Length: 208 / 314
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000099365 | syntaxin 1B |
| ENSG00000106089 | syntaxin 1A |
| ENSG00000111450 | syntaxin 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 17 | 11 | 14 |
| disruptive | 3 | 14 | 12 | 42 |
| missense | 3 | 14 | 12 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 9 | 19 |
| disruptive | 6 | 53 | 34 | 64 |
| missense | 4 | 39 | 24 | 46 |
PlasmoDB Total SNPs: 72
Non-coding: 52 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 1
Protein Length: 314 | Molecular Weight (kDa): 37.127
PDB ID(s): None
Isoelectric Point: 7.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000727 | Target SNARE coiled-coil homology domain |
| InterPro | IPR006011 | Syntaxin, N-terminal domain |
| InterPro | IPR010989 | SNARE |
| PFam | PF00804 | Syntaxin, N-terminal domain |
| PFam | PF05739 | Target SNARE coiled-coil homology domain |
| Superfamily | SSF47661 | SNARE |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19103232 | Plasmodium falciparum secretory pathway: characterization of PfStx1, a plasmamembrane Qa-SNARE. | Parish LA, Rayner JC | 10.1016/j.molbiopara.2008.11.011 |