PF3D7_0210800

Genome location: Pf3D7_02_v3:437,342..439,708(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.62	0.70
Trophozoite	not expressed	0.16	0.90
Schizont	possibly expressed	0.07	0.96
Gametocyte	not expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0210800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.394 | MFS: -3.606 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0307700)

Relative Growth Rate: 0.65 ± 0.17
Confidence: 4.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0307700)

Modification: Disrupted | RMgm-1775

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96190

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533710

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	24	4	15
disruptive	14	33	16	35
missense	14	33	15	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	34	17	23
disruptive	24	92	35	80
missense	22	68	26	58

PlasmoDB Total SNPs: 154

Non-coding: 131 | Synonymous: 7 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 415 | Molecular Weight (kDa): 50.155

UniProt ID(s): O96190

PDB ID(s): None

Isoelectric Point: 10.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895