PF3D7_0210900

Genome location: Pf3D7_02_v3:441,381..443,570(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex
Component	GO:0005634	nucleus
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.99	0.55
Trophozoite	expressed	0.88	0.53
Schizont	expressed	0.25	0.84
Gametocyte	expressed	0.65	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0210900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.822 | MFS: -1.794 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0307800)

Relative Growth Rate: 0.45 ± 0.27
Confidence: 4.02

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0307800)

Modification: Disrupted | RMgm-1776

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96191

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532396

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	13	4	20
disruptive	0	13	12	47
missense	0	13	12	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	25	9	17
disruptive	6	43	44	64
missense	2	33	40	41

PlasmoDB Total SNPs: 42

Non-coding: 31 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 284 | Molecular Weight (kDa): 32.542

UniProt ID(s): O96191

PDB ID(s): None

Isoelectric Point: 11.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596
31384004	Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodiumfalciparum blood-stage development.	Baumgarten S, Bryant JM, ..., Scherf A	10.1038/s41564-019-0521-7
31390575	Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality.	Hillier C, Pardo M, ..., Choudhary JS	10.1016/j.celrep.2019.07.019