About Gene List

PF3D7_0211100

Genome location: Pf3D7_02_v3:451,526..455,367(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite possibly expressed 0.16 0.91
Schizont not expressed 0.09 0.95
Gametocyte not expressed 0.21 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0211100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.519 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96192

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.04) with 2BVL (Global RMSD=16.72)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533160

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 49 17 71
disruptive 26 123 61 181
missense 24 117 59 168

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 89 37 68
disruptive 45 259 144 251
missense 38 234 127 190

PlasmoDB Total SNPs: 85

Non-coding: 10 | Synonymous: 33 | Nonsynonymous: 42 | Stop Codon: 0

Protein Information

Protein Length: 1121 | Molecular Weight (kDa): 135.781

UniProt ID(s): O96192

PDB ID(s): None

Isoelectric Point: 9.22

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097