About Gene List

PF3D7_0211300

Genome location: Pf3D7_02_v3:456,907..458,616(-)

Genome classification: Core

Function and Localization

Product Description: ubiquinol-cytochrome-c reductase complex assembly factor 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Process GO:0034551 mitochondrial respiratory chain complex III assembly
Process GO:0070131 positive regulation of mitochondrial translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 1.00
Trophozoite not expressed 0.05 0.96
Schizont not expressed 0.03 0.98
Gametocyte possibly expressed 0.19 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0211300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.074 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0308100)

  • Relative Growth Rate: 0.73 ± 0.14
  • Confidence: 5.36

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0308100)

Modification: Disrupted | RMgm-1777

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I661

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_138000

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 15 10 11
disruptive 0 13 11 21
missense 0 13 11 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 29 6 9
disruptive 3 42 30 57
missense 1 34 21 32

PlasmoDB Total SNPs: 96

Non-coding: 84 | Synonymous: 12 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 292 | Molecular Weight (kDa): 35.534

UniProt ID(s): Q8I661

PDB ID(s): None

Isoelectric Point: 9.28

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007129 Ubiquinol-cytochrome c chaperone, CBP3
InterPro IPR021150 Ubiquinol-cytochrome c chaperone/UPF0174
PFam PF03981 Ubiquinol-cytochrome c chaperone/UPF0174
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21