Product Description: UDP-N-acetylglucosamine transferase subunit ALG14, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: 2.4.1.141 (N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043541 | UDP-N-acetylglucosamine transferase complex |
| Function | GO:0004577 | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity |
| Process | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.14 | 0.91 |
| Schizont | expressed | 0.37 | 0.77 |
| Gametocyte | possibly expressed | 0.17 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0211600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.101 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0308400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0308400)
Modification: Disrupted | RMgm-1779
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96196
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.4.1.141 | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase | UDPUTPUMPEDTADiumycinUDPglucosebacitracinAmphomycinShowdomycin5-fluoro N-acetylglucosamineN-acetyl-D-glucosaminyl-diphosphodolicholP1-dolichyl P2-(2-O-ethyl-alpha-D-glucopyranosyl) diphosphate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102531
Most Similar Human Ortholog: Q96F25
TM-align score: 0.85 | RMSD: 2.73
Seq Identity: 0.29 | Length: 202 / 209
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000172339 | ALG14 UDP-N-acetylglucosaminyltransferase subunit |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 2 | 10 |
| disruptive | 2 | 9 | 4 | 17 |
| missense | 2 | 9 | 4 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 8 | 12 |
| disruptive | 3 | 28 | 23 | 43 |
| missense | 3 | 17 | 19 | 25 |
PlasmoDB Total SNPs: 31
Non-coding: 23 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 209 | Molecular Weight (kDa): 24.818
UniProt ID(s): O96196
PDB ID(s): None
Isoelectric Point: 9.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013969 | Oligosaccharide biosynthesis protein Alg14-like |
| PFam | PF08660 | Oligosaccharide biosynthesis protein Alg14-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |