About Gene List

PF3D7_0211900

Genome location: Pf3D7_02_v3:477,189..479,816(-)

Genome classification: Core

Function and Localization

Product Description: pseudouridine synthase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite expressed 0.72 0.61
Schizont expressed 0.29 0.82
Gametocyte possibly expressed 0.74 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0211900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.129 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96199

"Best" AlphaFill ligand hit: NXL (nxl104, bound form, Local RMSD=1.35) with 5GWA (Global RMSD=15.39)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134004

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 20 5 23
disruptive 4 44 22 58
missense 3 41 20 52

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 32 16 19
disruptive 15 86 40 105
missense 9 66 36 79

PlasmoDB Total SNPs: 103

Non-coding: 85 | Synonymous: 11 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 450 | Molecular Weight (kDa): 53.761

UniProt ID(s): O96199

PDB ID(s): None

Isoelectric Point: 9.77

Protein Domain Annotations:

Source Family ID Description
InterPro IPR020103 Pseudouridine synthase, catalytic domain superfamily
PFam N/A N/A
Superfamily SSF55120 Pseudouridine synthase, catalytic domain superfamily

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097