About Gene List

PF3D7_0212000

Genome location: Pf3D7_02_v3:479,683..481,854(+)

Genome classification: Core

Function and Localization

Product Description: GDP-fructose:GMP antiporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005794 Golgi apparatus
Function GO:0015297 antiporter activity
Function GO:0022857 transmembrane transporter activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.09 0.96
Trophozoite expressed 0.59 0.66
Schizont expressed 0.26 0.83
Gametocyte expressed 0.71 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0212000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.138 | MFS: -3.212 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0309400)

Modification: Disrupted | RMgm-4766

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96200

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104078

Most Similar Human Ortholog: Q96A29

TM-align score: 0.87 | RMSD: 2.57

Seq Identity: 0.20 | Length: 301 / 311

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000181830 solute carrier family 35 member C1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 16 9 21
disruptive 7 21 11 30
missense 6 19 9 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 25 13 19
disruptive 16 37 28 54
missense 11 26 23 45

PlasmoDB Total SNPs: 174

Non-coding: 150 | Synonymous: 15 | Nonsynonymous: 8 | Stop Codon: 1

Protein Information

Protein Length: 311 | Molecular Weight (kDa): 36.668

UniProt ID(s): O96200

PDB ID(s): None

Isoelectric Point: 9.2

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097