PF3D7_0212100

Genome location: Pf3D7_02_v3:483,322..489,702(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0034399	nuclear periphery
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.44	0.79
Trophozoite	expressed	0.92	0.52
Schizont	expressed	0.60	0.67
Gametocyte	possibly expressed	0.68	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0212100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.234 | MFS: -2.686 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0308900)

Modification: Disrupted | RMgm-1782

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96201

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.71) with 6JWU (Global RMSD=20.63)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533439

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	49	95	34	96
disruptive	185	400	185	382
missense	81	215	128	278

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	70	156	44	92
disruptive	273	665	250	454
missense	114	413	180	290

PlasmoDB Total SNPs: 512

Non-coding: 52 | Synonymous: 214 | Nonsynonymous: 244 | Stop Codon: 2

Protein Information

Protein Length: 1844 | Molecular Weight (kDa): 214.68

UniProt ID(s): O96201

PDB ID(s): None

Isoelectric Point: 7.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF141571	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
19765590	Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum.	Volz J, Carvalho TG, ..., Cowman AF	10.1016/j.ijpara.2009.09.002
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108