Product Description: ribosomal protein L12, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.18 | 0.91 |
| Trophozoite | expressed | 0.44 | 0.75 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | not expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0212200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -2.93 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96202
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100766
Most Similar Human Ortholog: P52815
TM-align score: 0.40 | RMSD: 2.91
Seq Identity: 0.29 | Length: 88 / 255
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000262814 | mitochondrial ribosomal protein L12 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 5 | 5 | 13 |
| disruptive | 1 | 16 | 14 | 26 |
| missense | 1 | 14 | 14 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 7 | 20 |
| disruptive | 7 | 40 | 33 | 51 |
| missense | 3 | 31 | 27 | 35 |
PlasmoDB Total SNPs: 124
Non-coding: 107 | Synonymous: 15 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 255 | Molecular Weight (kDa): 29.547
UniProt ID(s): O96202
PDB ID(s): None
Isoelectric Point: 9.97
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000206 | Ribosomal protein L7/L12 |
| InterPro | IPR013823 | Ribosomal protein L7/L12, C-terminal |
| InterPro | IPR014719 | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| PFam | PF00542 | Ribosomal protein L7/L12, C-terminal |
| Superfamily | SSF54736 | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |