About Gene List

PF3D7_0212400 (NUP390)

Genome location: Pf3D7_02_v3:494,337..507,898(-)

Genome classification: Core

Function and Localization

Product Description: nucleoporin NUP390, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0034399 nuclear periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.19 0.49
Trophozoite expressed 1.58 0.30
Schizont expressed 0.77 0.63
Gametocyte expressed 1.19 0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0212400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.91 | MFS: -2.893 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0309200)

  • Relative Growth Rate: 0.04 ± 0.18
  • Confidence: 4.84

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0309200)

Modification: Tagged | RMgm-5244

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533473

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 42 192 110 198
disruptive 247 560 273 690
missense 121 427 228 567

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 68 367 148 225
disruptive 423 1090 474 1015
missense 200 820 380 718

PlasmoDB Total SNPs: 534

Non-coding: 118 | Synonymous: 171 | Nonsynonymous: 245 | Stop Codon: 0

Protein Information

Protein Length: 4091 | Molecular Weight (kDa): 494.213

UniProt ID(s): O96204

PDB ID(s): None

Isoelectric Point: 8.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
36040030 TurboID Identification of Evolutionarily Divergent Components of the Nuclear PoreComplex in the Malaria Model Plasmodium berghei. Ambekar SV, Beck JR, Mair GR 10.1128/mbio.01815-22