About Gene List

PF3D7_0212500 (NUP434)

Genome location: Pf3D7_02_v3:508,665..521,769(+)

Genome classification: Core

Function and Localization

Product Description: nucleoporin NUP434, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0034399 nuclear periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.72 0.31
Trophozoite expressed 2.15 0.16
Schizont expressed 1.23 0.46
Gametocyte expressed 1.45 0.34

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0212500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.048 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0309400)

Modification: Tagged | RMgm-5245

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533497

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 63 165 103 195
disruptive 283 539 264 628
missense 131 357 196 464

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 91 312 137 217
disruptive 466 946 457 845
missense 209 631 345 553

PlasmoDB Total SNPs: 672

Non-coding: 154 | Synonymous: 285 | Nonsynonymous: 233 | Stop Codon: 0

Protein Information

Protein Length: 3990 | Molecular Weight (kDa): 477.854

UniProt ID(s): O96205

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
36040030 TurboID Identification of Evolutionarily Divergent Components of the Nuclear PoreComplex in the Malaria Model Plasmodium berghei. Ambekar SV, Beck JR, Mair GR 10.1128/mbio.01815-22