PF3D7_0212700

Genome location: Pf3D7_02_v3:524,470..526,067(-)

Genome classification: Core

Function and Localization

Product Description: SRR1-like protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Process	GO:0007623	circadian rhythm
Process	GO:0007017	microtubule-based process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	expressed	0.08	0.94
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.20	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0212700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -3.01 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0309600)

Relative Growth Rate: 0.73 ± 0.19
Confidence: 4.76

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0309600)

Modification: Disrupted | RMgm-1785

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96208

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533042

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	22	11	36
disruptive	16	84	45	103
missense	9	65	37	81

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	51	20	37
disruptive	44	161	61	125
missense	27	120	44	91

PlasmoDB Total SNPs: 82

Non-coding: 29 | Synonymous: 34 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 447 | Molecular Weight (kDa): 53.925

UniProt ID(s): O96208

PDB ID(s): None

Isoelectric Point: 7.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012942	SRR1-like domain
InterPro	IPR040044	SRR1-like protein
PFam	PF07985	SRR1-like domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097