About Gene List

PF3D7_0213200

Genome location: Pf3D7_02_v3:539,809..541,065(-)

Genome classification: Core

Function and Localization

Product Description: mitochondrial respiratory chain complex II subunit, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Component GO:0045273 respiratory chain complex II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite possibly expressed 0.33 0.79
Schizont possibly expressed 0.10 0.93
Gametocyte not expressed 0.38 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0213200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.141 | MFS: -3.225 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0310100)

Modification: Tagged | RMgm-4966

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96213

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125519

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 4 4 12
disruptive 2 6 8 23
missense 2 6 7 20

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 9 8 10
disruptive 7 23 15 43
missense 3 18 14 38

PlasmoDB Total SNPs: 74

Non-coding: 67 | Synonymous: 2 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 126 | Molecular Weight (kDa): 15.342

UniProt ID(s): O96213

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
33651838 Complexome profile of Toxoplasma gondii mitochondria identifies divergentsubunits of respiratory chain complexes including new subunits of cytochrome bc1complex. Maclean AE, Bridges HR, ..., Sheiner L 10.1371/journal.ppat.1009301
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21