About Gene List

PF3D7_0213300

Genome location: Pf3D7_02_v3:541,071..542,094(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.03 0.98
Trophozoite no data 0.30 0.81
Schizont no data 0.04 0.97
Gametocyte no data 0.47 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0213300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.124 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3B6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125519

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 2 2 6
disruptive 0 5 2 8
missense 0 5 2 4

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 5 5 6
disruptive 4 14 7 21
missense 2 8 6 13

PlasmoDB Total SNPs: 38

Non-coding: 36 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 78 | Molecular Weight (kDa): 9.584

UniProt ID(s): C6S3B6

PDB ID(s): None

Isoelectric Point: 11.96

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31339607 Identification of the Toxoplasma gondii mitochondrial ribosome, andcharacterisation of a protein essential for mitochondrial translation. Lacombe A, Maclean AE, ..., Sheiner L 10.1111/mmi.14357