Product Description: tetratricopeptide repeat protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Function | GO:0051879 | Hsp90 protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.09 | 0.95 |
Trophozoite | not expressed | 0.31 | 0.82 |
Schizont | not expressed | 0.13 | 0.92 |
Gametocyte | not expressed | 0.40 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0213500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.843 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96215
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_115977
Most Similar Human Ortholog: Q15785
TM-align score: 0.35 | RMSD: 1.88
Seq Identity: 0.28 | Length: 112 / 460
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000025772 | translocase of outer mitochondrial membrane 34 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 23 | 16 | 35 |
disruptive | 5 | 43 | 38 | 70 |
missense | 5 | 42 | 37 | 69 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 8 | 55 | 19 | 33 |
disruptive | 13 | 123 | 57 | 140 |
missense | 10 | 109 | 50 | 95 |
PlasmoDB Total SNPs: 149
Non-coding: 124 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 460 | Molecular Weight (kDa): 55.225
UniProt ID(s): O96215
PDB ID(s): None
Isoelectric Point: 8.65
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
InterPro | IPR019734 | Tetratricopeptide repeat |
PFam | PF13181 | Tetratricopeptide repeat |
Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |