About Gene List

PF3D7_0213500

Genome location: Pf3D7_02_v3:543,700..546,217(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0051879 Hsp90 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.09 0.95
Trophozoite not expressed 0.31 0.82
Schizont not expressed 0.13 0.92
Gametocyte not expressed 0.40 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0213500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.843 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96215

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_115977

Most Similar Human Ortholog: Q15785

TM-align score: 0.35 | RMSD: 1.88

Seq Identity: 0.28 | Length: 112 / 460

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000025772 translocase of outer mitochondrial membrane 34

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 23 16 35
disruptive 5 43 38 70
missense 5 42 37 69

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 55 19 33
disruptive 13 123 57 140
missense 10 109 50 95

PlasmoDB Total SNPs: 149

Non-coding: 124 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 460 | Molecular Weight (kDa): 55.225

UniProt ID(s): O96215

PDB ID(s): None

Isoelectric Point: 8.65

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
InterPro IPR019734 Tetratricopeptide repeat
PFam PF13181 Tetratricopeptide repeat
Superfamily SSF48452 Tetratricopeptide-like helical domain superfamily

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097