About Gene List

PF3D7_0213600

Genome location: Pf3D7_02_v3:546,482..555,294(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.11 0.95
Trophozoite not expressed 0.28 0.85
Schizont not expressed 0.15 0.91
Gametocyte expressed 1.76 0.27

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0213600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.387 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0310500)

Modification: Disrupted | RMgm-1790

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWS3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532415

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 22 93 49 123
disruptive 88 209 124 380
missense 53 177 102 321

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 36 174 83 170
disruptive 176 479 248 532
missense 83 363 200 403

PlasmoDB Total SNPs: 464

Non-coding: 238 | Synonymous: 133 | Nonsynonymous: 93 | Stop Codon: 0

Protein Information

Protein Length: 2418 | Molecular Weight (kDa): 292.29

UniProt ID(s): A0A143ZWS3

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596