About Gene List

PF3D7_0213800

Genome location: Pf3D7_02_v3:558,585..560,594(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020007 apical complex
Component GO:0045177 apical part of cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.06 0.96
Schizont not expressed 0.01 0.99
Gametocyte expressed 0.65 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0213800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.384 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0310700)

Modification: Tagged | RMgm-4953

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96218

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158724

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 26 18 34
disruptive 15 40 27 70
missense 14 39 26 63

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 46 22 47
disruptive 26 104 63 128
missense 16 85 54 91

PlasmoDB Total SNPs: 43

Non-coding: 1 | Synonymous: 21 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 669 | Molecular Weight (kDa): 80.152

UniProt ID(s): O96218

PDB ID(s): None

Isoelectric Point: 8.24

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
29269729 A conserved ankyrin repeat-containing protein regulates conoid stability,motility and cell invasion in Toxoplasma gondii. Long S, Anthony B, Drewry LL, Sibley LD 10.1038/s41467-017-02341-2
33705380 Molecular characterization of the conoid complex in Toxoplasma reveals itsconservation in all apicomplexans, including Plasmodium species. Koreny L, Zeeshan M, ..., Waller RF 10.1371/journal.pbio.3001081