About Gene List

PF3D7_0213900

Genome location: Pf3D7_02_v3:560,872..565,395(-)

Genome classification: Core

Function and Localization

Product Description: RTR1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.44 0.79
Trophozoite expressed 0.41 0.77
Schizont possibly expressed 0.07 0.96
Gametocyte expressed 0.50 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0213900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.184 | MFS: -2.747 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96219

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.3.16 protein-serine/threonine phosphatase ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126967

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 1166

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000288642 cerebellar degeneration related protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 52 26 59
disruptive 70 152 77 184
missense 38 111 53 145

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 27 98 37 58
disruptive 131 278 138 238
missense 71 186 103 175

PlasmoDB Total SNPs: 344

Non-coding: 98 | Synonymous: 118 | Nonsynonymous: 128 | Stop Codon: 0

Protein Information

Protein Length: 1166 | Molecular Weight (kDa): 139.39

UniProt ID(s): O96219

PDB ID(s): None

Isoelectric Point: 5.56

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007308 Rtr1/RPAP2 domain
PFam PF04181 Rtr1/RPAP2 domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28288121 A genetic system to study Plasmodium falciparum protein function. Birnbaum J, Flemming S, ..., Spielmann T 10.1038/nmeth.4223