Product Description: protein transport protein SEC31
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030127 | COPII vesicle coat |
| Component | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0070971 | endoplasmic reticulum exit site |
| Component | GO:0030430 | host cell cytoplasm |
| Function | GO:0005198 | structural molecule activity |
| Process | GO:0090114 | COPII-coated vesicle budding |
| Process | GO:0090110 | COPII-coated vesicle cargo loading |
| Process | GO:0007029 | endoplasmic reticulum organization |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0044053 | translocation of peptides or proteins into host cell cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.95 | 0.27 |
| Trophozoite | expressed | 1.45 | 0.32 |
| Schizont | expressed | 1.32 | 0.37 |
| Gametocyte | expressed | 0.93 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0214100
Resistome Missense Mutations: P1290S
Resistome Compounds with Missense Mutations: MMV665794
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.209 | MFS: -2.744 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0311000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0311000)
Modification: Tagged | RMgm-4473
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96221
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101250
Most Similar Human Ortholog: E9PKR7
TM-align score: 0.90 | RMSD: 2.52
Seq Identity: 0.25 | Length: 342 / 1471
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000075826 | SEC31 homolog B, COPII coat complex component |
| ENSG00000138674 | SEC31 homolog A, COPII coat complex component |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 75 | 38 | 87 |
| disruptive | 31 | 112 | 61 | 175 |
| missense | 12 | 95 | 49 | 150 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 139 | 48 | 100 |
| disruptive | 54 | 215 | 112 | 269 |
| missense | 27 | 175 | 99 | 195 |
PlasmoDB Total SNPs: 186
Non-coding: 76 | Synonymous: 84 | Nonsynonymous: 26 | Stop Codon: 0
Protein Length: 1471 | Molecular Weight (kDa): 166.709
PDB ID(s): None
Isoelectric Point: 6.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR024298 | Ancestral coatomer element 1, Sec16/Sec31 |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| InterPro | IPR040251 | Protein transport protein SEC31-like |
| PFam | PF12931 | Ancestral coatomer element 1, Sec16/Sec31 |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 11591825 | Evidence for a role for a Plasmodium falciparum homologue of Sec31p in the exportof proteins to the surface of malaria parasite-infected erythrocytes. | Adisa A, Albano FR, ..., Tilley L | 10.1242/jcs.114.18.3377 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 35865221 | Targeted protein degradation using deGradFP in Trypanosoma brucei | Ishii M, Akiyoshi B | 10.12688/wellcomeopenres.17964.2 |
| 35120648 | Co-adaptor driven assembly of a CUL3 E3 ligase complex | Akopian D, McGourty CA, Rape M | 10.1016/j.molcel.2022.01.004 |
| 36301095 | Sar1 Interacts with Sec23/Sec24 and Sec13/Sec31 Complexes: Insight into ItsInvolvement in the Assembly of Coat Protein Complex II in the MicrosporidianNosema bombycis | Sun F, Wang R, ..., Shen Z | 10.1128/spectrum.00719-22 |
| 35727050 | Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes | Sharif M, Bangs JD | 10.1128/msphere.00188-22 |