Product Description: ribosomal protein L13, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005840 | ribosome |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0017148 | negative regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.24 | 0.84 |
| Schizont | expressed | 0.05 | 0.97 |
| Gametocyte | not expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0214200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.255 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0311100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96222
"Best" AlphaFill ligand hit: SPD (n-(2-amino-propyl)-1,4-diaminobutane, Local RMSD=0.45) with 5HKV (Global RMSD=1.64)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101118
Most Similar Human Ortholog: E5RJI7
TM-align score: 0.81 | RMSD: 2.43
Seq Identity: 0.24 | Length: 137 / 212
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000172172 | mitochondrial ribosomal protein L13 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 8 | 12 |
| disruptive | 1 | 9 | 6 | 12 |
| missense | 1 | 9 | 6 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 19 | 10 | 19 |
| disruptive | 3 | 19 | 11 | 36 |
| missense | 1 | 14 | 9 | 29 |
PlasmoDB Total SNPs: 98
Non-coding: 90 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 212 | Molecular Weight (kDa): 24.572
UniProt ID(s): O96222
PDB ID(s): None
Isoelectric Point: 10.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005822 | Ribosomal protein L13 |
| InterPro | IPR005823 | Ribosomal protein L13, bacterial-type |
| InterPro | IPR023563 | Ribosomal protein L13, conserved site |
| InterPro | IPR036899 | Ribosomal protein L13 superfamily |
| PFam | PF00572 | Ribosomal protein L13 |
| Superfamily | SSF52161 | Ribosomal protein L13 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29626096 | The mitochondrial ribosomal protein L13 is critical for the structural andfunctional integrity of the mitochondrion in Plasmodium falciparum. | Ke H, Dass S, ..., Vaidya AB | 10.1074/jbc.RA118.002552 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |